Genetics and Biochemistry News

Dr. Rajan Sekhon and team lead to 2.4 million NFS grant

Associate professor Rajan Sekhon along with a team of researchers at Clemson University and partner organizations have received a $2.4 million, four-year grant to map genes that control leaf senescence in corn. Funded by the National Science Foundation through both the Plant Genome Research Program and the Cross-Directorate Activities program, this project aims to sustain photosynthesis longer, improve yield stability and support smarter on-farm nitrogen use.

“Our goal is to set the timing of leaf senescence so plants stay productive when it counts and still finish cleanly for harvest, which can also help keep more nitrogen working on the farm,” Sekhon said.

This project will determine when senescence, which is the aging process where plants recycle nutrients, begins and how quickly it proceeds. Sekhon’s group will map the genes and regulatory switches that control senescence by using a systems genetics approach that integrates physiology, metabolomics, transcriptomes, chromatin accessibility and single cell RNA sequencing. Artificial intelligence, primarily large language models (LLMs) and machine learning, along with advanced statistical methods, will combine these data to pinpoint genes and regulatory switches that set senescence timing in corn and possibly other crops.

“While we’re focused on the process of senescence, we are developing methods and datasets that can translate to other traits and crops,” he said.

Nitrogen is essential for protein formation in corn because it is a fundamental component of amino acids, the building blocks of all proteins.

“Most kernel protein is storage protein with limited amino acid balance, so lowering total kernel protein does not automatically reduce nutritional value. If we get the timing of leaf senescence right, we can keep yield steady and, over time, help more nitrogen remain on the farm.”

Read more in the Clemson News article.

Alum and biochemistry student recognized by national graduate research fellowships program

Alumni Christine Hart ’18 and biochemistry major Caroline Argenti were recognized by the prestigious National Science Foundation’s (NSF) Graduate Research Fellowship Program, receiving three years of financial support for graduate study.

The Graduate Research Fellowship Program supports outstanding students early in their graduate school careers based on their demonstrated potential for significant research achievements in science, technology, engineering and mathematics or in STEM education. Recipients receive a $37,000 stipend and a full cost of education allowance, which covers their tuition and mandatory fees.

Caroline Argenti’s research focuses on expanding the field of nanotechnology with an emphasis on RNA (ribonucleic acid) therapeutics. Caroline has also been awarded the Goldwater Scholarship in 2024. After she graduates, she plans to pursue a Ph.D. in biomedical engineering at the University of North Carolina at Chapel Hill.

Christine Hart ‘18, researches the impact of global and anthropogenic changes on insect communities and how to address insect declines through research-based management solutions and equitable science education for K-12 students with language-based learning differences. She currently runs a small business providing educational support and consulting for students with learning disabilities and works part-time at Clemson’s Coastal Research and Education Center in a vegetable entomology lab run by Tom Bilbo, assistant professor of plant and environmental sciences.

Read more in the Clemson News article.

Gracie Dellinger ’24 awarded prestigious graduate research fellowship

Gracie Dellinger graduated in May with degrees in genetics and microbiology

Gracie Dellinger ’24, recent genetics and microbiology alum, was one of the six Clemson members recognized with the country’s most prestigious STEM-focused graduate research fellowship, awarded annually through the National Science Foundation (NSF).


The NSF’s Graduate Research Fellowship program helps ensure the quality, vitality and diversity of the country’s scientific and engineering workforce by supporting outstanding students pursuing research-based graduate degrees at accredited United States institutions.


Gracie, originally from McClellanville, South Carolina, was a part of the Clemson Honors College and has been performing undergraduate research in EPIC with Dr. Kim Paul since the summer after her junior year of high school, focusing on the parasite that causes African Sleeping Sickness, a disease that can be fatal if left untreated. Last summer, Gracie attended a Research Experience for Undergraduates at UNC Chapel Hill, exploring different adaptations of an intestinal pathogen responsible for a hospital-acquired disease called C. difficile infection.


Gracie will be attending Duke University School of Medicine in the fall, where she plans to pursue a Ph.D. in molecular genetics and microbiology. She was also awarded a fellowship called the James P. Duke Fellowship, which aims to attract and develop outstanding scholars at Duke.