Genetics and Biochemistry News

Man’s best friend? Dr. Kelsey Witt Dillon’s research proves so

How long ago the bond between dog and man was first formed is something scientists haven’t been able to ascertain.

New research involving Kelsey Witt Dillon, an assistant professor in the Clemson University Department of Genetics and Biochemistry and the Center for Human Genetics, is part of new research that now suggests indigenous people in interior Alaska had formed relationships with the ancestors of today’s dogs near the end of the Ice Age — a time at least 2,000 years earlier than previously thought.

“Dogs were the first animal to be domesticated, but it was so long ago that we don’t really know the details of when and how,” said Witt Dillon, a computational biologist and population geneticist whose research focuses on the history of dogs in the Americas. “Any time we come across archeological samples of canids — dogs, wolves or coyotes — we’re interested in learning more about them and their relationship with humans to try to shed light on that.”

The researchers used a database of 111 large canid specimens. Included was the tibia of an adult canine about 12,000 years old and an 8,100-year-old canine jawbone excavated. The scientists determined that the canines from which these two bones came from had regularly eaten salmon, a diet choice that wasn’t typical of canine, who typically hunted land animals for food. Researchers say these dogs likely were fed by humans or scavenged salmon left by humans.

“We have evidence that sometimes people had a very loose association with dogs, where the dogs would be around, but they didn’t have owners and they weren’t being actively managed in any way,” she said. “It was a relationship where the humans had some benefit from the dogs being around, maybe some protection from wolves, and the dogs got food and a bit of safety, too. The pet idea is newer and the breeds as we know them are newer.”

Witt Dillon said the goal of the project was to consider different lines of evidence at once to try get a picture of what human-dog and human-wolf interactions were like.

“We see a lot of evidence of people feeding dogs and taking care of them, and we see this through time. People have valued dogs for thousands of years. I think it’s a cool thing to see that we’ve had this very long, lasting relationship,” she said.

Dr. Witt Dillon’s research has been published in “Late Pleistocene onset of mutualistic human/canid (Canis spp.) relationships in subarctic Alaska.”

Read more and watch the video in the Clemson News article.

Biochemistry alum named Dean of USC School of Medicine – Greenville

Biochemistry alum Dr. Phyllis MacGilvray ’96 became interested in medicine at an early age because of her relationship with her family doctor.

“I have a curious mind and was always asking, ‘Why?’ I found science fascinating because it gave me an avenue to finding answers,” she said. “Medicine was just a natural fit for me.”

In July, the University of South Carolina School of Medicine Greenville named Dr. MacGilvray, a family medicine practitioner of over 20 years, its dean.

Dr. MacGilvray earned her doctor of medicine degree in 2002 from the Medical University of South Carolina in Charleston before completing her residency in family medicine at the University of Vermont, followed by academic leadership positions at Eastern Virginia Medical School, Naval Medical Center Camp Lejeune and at the University of Texas Health San Antonio.

She then returned home to South Carolina in 2018 to take a position with Prisma Health—Upstate as vice chair for academic affairs in family medicine, becoming department chair in 2020 and leading the development of two new graduate medical education programs, which tripled the number of family medicine residency positions at Prisma.

Dr. MacGilvray will serve as dean for a two-year term – a time in which she plans to bolster the school’s research footprint and elevate the school’s lifestyle medicine mission. She is the first medical school dean in the country who is board-certified in lifestyle medicine, which focuses on using evidence-based lifestyle interventions to prevent, treat and reverse chronic diseases.

“Learning from the very first day of medical school how to educate patients holistically is only going to improve the care of their patients down the line,” Dr. MacGilvray said.

Read more in the Clemson News article.

Luo receives USDA grant

Considering the world’s growing population and less land being available for farming, it’s becoming more important than ever to increase nutritional quality and crop yield of food crops. One way to achieve this is by genetically modifying a plant by introducing a foreign gene (called a transgene) from another organism, essentially giving the plant a new trait not naturally present in its genome.

This often enhances a plant’s resistance to pests, diseases and environmental stresses, improves its nutritional value. Plant’s traits can also be improved by modifying the genes they already have through gene-editing technology.

However, when foreign genes are introduced into target crops using the transgenic approach or by manipulating endogenous gene expression in target crops using genome editing for trait modification, some unneeded DNA may end up permanently residing in the host genomes of the final transgenic products, which raises questions of potential hazards or adverse effects to the host, environment and human health. Professor Hong Luo and his lab have been studying this genome editing in crops.

“The unnecessary DNA that gets into the transgenic plants with the target gene need to be removed,” says professor Hong Luo.

One way to remove them is by using site-specific DNA recombinases. Site-specific recombinases recognize specific DNA sequences by flanking the desirable gene with target sequences that the recombinase can recognize and excise.

Professor Luo has received a $650,000 grant from the U.S. Department of Agriculture to study these unintended consequences of three site-specific DNA recombination systems commonly used to genetically engineer target crops.

In this study, Luo will study three different recombinase genes — Cre, FLP and PhiC31 — in plants creeping bentgrass and Arabidopsis by investigating whether there are unintended off-target effects to host genomes, epigenomes and phenotypes and whether they negatively or positively affect plant traits and present hazards to the environment.

“This will give us an idea about what aspects those recombinases impact in which particular plant species,” he said.

Read more and watch the video in the Clemson News article.

December Graduate – Olivia Eierman ’24

When choosing a college, STEM opportunities were important for December genetics graduate Olivia Eierman ’24. Originally from Long Island, NY, Olivia came a long way to make Clemson her home.


“I chose Clemson because of its many opportunities in STEM related fields as well as hometown feel.”


With cluster engineering and biological sciences as her minors, Olivia’s favorite class while she was a student was Engineering Analysis of Physiological Processes (BIOE 3100) with Professor Dr. Heather Dunn. Olivia’s interest in engineering shined through her years at Clemson.


“Throughout Clemson I was involved in Engineers for developing communities where I was the project manager of the Cange Hospital Optimization team.”


In addition, Olivia served as the treasurer of Chaarg a health and wellness organization for girls at Clemson and was a member in Delta Zeta sorority. Chaarg, which stands for Changing Health, Attitudes + Actions to Recreate Girls, provides a holistically healthy + safe community for girls. Olivia also spent a summer studying abroad in Europe.


“My favorite Clemson memory was studying abroad in the summer of 2023 on a faculty directed trip with the bioengineering department watching the Eiffel tower twinkle on the last night of our trip!”


After graduation Olivia plans to go back to Long Island and work in a neuropathology lab and hopes to pursue a master’s or apply for PA school in the future. In her free time, Olivia enjoys taking her puppy on walks at the dykes, enjoying football games with friends and cooking.


Congrats, Olivia!

G&B hosts Research in Progress Symposium

On Monday, December 16th, the Department of Genetics and Biochemistry held its semi-annual Research in Progress (RIP) Symposium, where graduate students give a 20-minute presentation on their research. This year’s presenters included Sabrina Pizzaro, Xiaotong Chen, Amara Onoh and Chia-Lun (Allen) Wu.

Titles of Presentations


Sabrina Pizzaro: Putative Sodium/Proton Exchangers in Trypanosoma brucei


Xiaotong Chen: How miR164 fine tuning plant growth to balance abiotic stress response and potential off target activity in DNA recombinase


Amara Onoh: Biochemical Characterization of MEILB2/HSF2BP as a Key Factor in Meiotic Homologous Recombination


Chia-Lun (Allen) Wu: Abnormal Trafficking and Processing of Multiple Matrix Metalloproteinases Drives Cartilage Defects in PMM2-CDG

December Grad – Bryson Woodard ’24

For the last few years, Bryson Woodard BS ’23, MS ’24 has been a staple around the Department of Genetics and Biochemistry and the Eukaryotic Pathogens Innovation Center (EPIC), first working as a lab manager for the Morris lab as a biological sciences undergraduate and then as a graduate student.

Bryson graduates on Thursday with a master’s in biochemistry and molecular biology. With Dr. Meredith Morris as his PI, Bryson’s research focused on assessing glycosomal heterogeneity in the parasitic kinetoplastid Trypanosoma brucei.

“We are interested in the diversity of glycosomes, which are essential metabolic organelles within the Trypanosomes; previous research findings suggest that not all glycosomes are the same.”

To assess this diversity, Bryson and his lab mates use an endogenous tagging technique to attach fluorescent protein tags to essential glycosomal membrane proteins. These tagged membrane proteins allow analyzation of glycosomal diversity using fluorescence expansion microscopy and advanced forms of flow cytometry.

In his free time, Bryson enjoys visiting local coffee shops, hiking, reading, and spending time with friends. His favorite moment while at Clemson was in his undergrad years when it snowed.

“A couple of friends and I went sledding at the dikes and ended up meeting Dabo, such a cool experience!”

After graduation, Bryson plans to work as a phlebotomist while he applies to medical school.

“I would like to thank my lab and everyone in EPIC/B&G for all of their support throughout this process, awesome people have truly made all the difference!”

December Grad – Helen Kiser ’24

December genetics graduate Helen Kiser ’24 has made the most of her time here at Clemson – whether she was performing research, going to football games, volunteering or studying with friends at the library.

Originally from Maryville, TN, Helen’s minor was biological sciences, which led her to be a part of Dr. Antonio Baeza’s lab, in the Department of Biological Sciences, where she performed mitogenomic research on marine species.

“In my time being a part of this lab, I’ve been able to publish a manuscript, present posters at many conferences/symposiums, and present an oral presentation this past week at the BioSci Undergraduate Research Symposium.”

In her free time at Clemson, Helen enjoyed trying out a new recipe, painting, finding new hiking spots, spending time with friends and volunteering with the Greenville County Parks and Recreation program Camp Spearhead Weekend Program, which gives fun weekend activities for people with special needs.

“I would say some of my favorite moments here have either been game days or just normal days working and hanging out with my friends in the library (specifically the round tables on “the fifth floor!).”

Helen is currently waiting to hear back from the genetic counseling programs she applied to. Until then, she will be taking a gap semester to take some needed time off and waiting to hear back from the other jobs and grad schools she applied for.


“I want to say a big thank you to everyone part of my Clemson journey for making it as great as it has been! Being an out-of-state student was initially quite daunting, but the tight-knit nature of the department gave me the opportunity to make many friends-for-life!”

Faculty and students receive grants – Fall 2024

Dr. Hong Luo has received a $650,000 grant from the U.S. Department of Agriculture to study the unintended consequences of three site-specific DNA recombination systems commonly used to genetically engineer target crops.

5th year Ph.D. student in Dr. Jennifer Mason’s lab Josh Turner was recently awarded an Environmental Mutagenesis and Genomics Society (EMGS) travel grant to attend the EMGS annual meeting in Palm Springs, CA.

Drs. Trudy Mackay and Robert Anholt have been awarded a $170,000 grant from the Cure Sanfilippo Foundation. The grant will be used to utilize Drosophila models of Sanfilippo A and B (also called mucopolysaccharidosis (MPS) IIIA and IIIB) to screen FDA-approved drugs that may ameliorate the symptoms and disease progression of these devastating pediatric diseases, also called “Childhood Alzheimers.”

Faculty and students recognized with honors – Fall 2024

Director of the Eukaryotic Pathogens Innovations Center (EPIC) and professor of Genetics and Biochemistry Dr. Kerry Smith has taken a role with the Clemson University School of Health Research (CUSHR) as campus research director for the Prisma Health Education and Research Institute (PHERI).

Dr. Robert Anholt served on NIGMS COBRE Phase 1 reviews – Special Emphasis Panel/Scientific Review Group 2024/10 ZGM1 RCB-T (C1).

Ph.D. student in Dr. Jim Morris’ lab Sabrina Pizarro has been awarded an EPIC Graduate Translational Research Assistantship.

Dr. Alex Feltus was interviewed by WYFF4 about artificial intelligence and using it in the classroom and beyond.

Authority Magazine recently highlighted Professor Shahid Mukhtar’s work and career journey in science in the article, “AgTech: Shahid Mukhtar of Clemson University on The New Technologies That Are Revolutionizing Agriculture.”

At the American Society of Microbiology Joint Branch Meeting of South Carolina, biochemistry and molecular biology master’s student Bryson Woodard received an Honorable Mention for his poster presentation titled, “Construction and Characterization of Transgenic Cell Lines for the Analysis of Glycosome Heterogeneity in Trypanosoma brucei“.

At the Clemson vs Virgina game on October 19th, Dr. Trudy Mackay was featured as professor of game.

Dr. Robert Anholt was invited to deliver a virtual scientific presentation skills workshop for the University of Chile in Santiago. In addition, he has been appointed a guest professor, in the Master in Genetics Program and Program of Human Genetics at the Institute of Biomedical Sciences within the Department of Neuroscience at the University of Chile.

Elizabeth Caldwell, senior genetics major, was selected as a finalist for the Rhodes Scholarship, one of the most prestigious and selective major fellowships available to American college students.

At the American Society of Microbiology Joint Branch Meeting of South Carolina, biochemistry undergraduate Hayeon Cho received an Honorable Mention for her poster presentation titled, “Determination of the role of one cathepsin C-like protease, TgCPC2, in Toxoplasma gondii infection.”

Dr. Alex Feltus and Ph.D. candidate Xusheng Ai released open-source generative AI software called GEMDiff that can “deep fake” gene expression in diseased tissue to look like gene expression in normal tissue.

Dr. Robert Anholt is a member of the Intellectual & Real Property Committee of the Greenwood Genetic Center and serves on the planning committee for the 2025 NIDA Animal Genetics Consortium meeting.

Clemson News featured an article spotlighting Drs. Trudy Mackay and Robert Anholt’s research of how fruit flies could help find treatment for “childhood Alzheimer’s.”

Faculty publish articles – Fall 2024