Month: November 2024

At the American Society of Microbiology Joint Branch Meeting of South Caroina (SC ASM) on November 9th, biochemistry and molecular biology master’s student Bryson Woodard received an Honorable Mention for his poster presentation titled, “Construction and Characterization of Transgenic Cell Lines for the Analysis of Glycosome Heterogeneity in Trypanosoma brucei“.

Bryson works in Dr. Meredith Morris’ lab in the Eukaryotic Pathogens Innovation Center (EPIC). The lab focuses on Trypanosoma brucei (the causative agent of African Sleeping Sickness) as a model organism and seeks to explore and close knowledge gaps within the parasite’s cellular biology.

“We are interested in the diversity of glycosomes, which are essential metabolic organelles within the Trypanosomes; previous research findings suggest that not all glycosomes are the same.”

To assess this diversity, Bryson and his lab mates use an endogenous tagging technique to attach fluorescent protein tags to essential glycosomal membrane proteins. These tagged membrane proteins allow analyzation of glycosomal diversity using fluorescence expansion microscopy and advanced forms of flow cytometry.

“To date, we have successfully attached our first fluorescent tag to our selected membrane proteins, subsequent attachment of additional tags and analysis is to follow.”

Attending the SC ASM fall meeting was an excellent experience for Bryson, where he was able to learn more about microbiological research happening in our state, network with other scientists and faculty and further prepare for his career as a physician.

“I am honored to have received an honorable mention for my poster presentation. I want to thank the conference organizers, my advisor, Dr. Meredith Morris and my lab mates for supporting me in these endeavors.”

Authority Magazine recently highlighted Professor Shahid Mukhtar’s work and career journey in science in the article, “AgTech: Shahid Mukhtar of Clemson University On The New Technologies That Are Revolutionizing Agriculture.” The interview for the article is done by Martita Mestey and the questions asked give great insight into Dr. Mukhtar’s life and career.

Read the article.

Elizabeth Caldwell, senior genetics major, has been selected as a finalist for the Rhodes Scholarship, one of the most prestigious and selective major fellowships available to American college students.

The Rhodes Scholarship, a fully funded postgraduate award which enables talented young people from around the world to study at the University of Oxford, is recognized worldwide as the oldest and most well-known scholarship for academic excellence. Rhode scholars are chosen based on those who demonstrate academic excellence, the energy to use their talents to the fullest, and attributes such as truth, courage, kindness, devotion to duty, moral force of character and instincts to lead.

Elizabeth, who researches rare diseases and advocates for the disability community, was recently announced as Clemson’s 5th Truman Scholar, a federally funded scholarship granted to U.S. undergraduate students for demonstrated leadership potential, academic excellence and a commitment to public service.

Elizabeth is also part of the National Scholars Program, Clemson’s most selective university-wide merit scholarship program. National Scholars are selected through a rigorous process that identifies students with the highest levels of intellectual vision and community engagement.

“A brilliant scientist and determined advocate, Elizabeth’s remarkable accomplishments are eclipsed only by her steadfast and inspirational commitment to making our campus, community, and society more welcoming and accessible,” said Sarah Winslow, inaugural dean of the Clemson University Honors College.

Elizabeth is actively engaged on campus and in the community. She is part of associate professor Michael Sehorn’s lab, which explores DNA repair pathways, serves as the only undergraduate student on Clemson’s Accessibility Commission, and founded Tigers 4 Accessibility, Clemson’s first and only student organization dedicated to creating a more inclusive and accessible campus culture and physical environment.

In addition, Elizabeth acts as a volunteer at the Clemson Free Clinic, a local medical center that provides health care to the area’s low-income population, where she created a Mobility Aid Program that raised $3,000 to offset medical equipment costs for patients.

Elizabeth is one of approximately 800 students nominated nationwide for the Rhodes Scholarship, competing for 32 spots. She is one of 15 finalists from the district representing South Carolina, Georgia and North Carolina. She interviews for the award on November 15 and 16.

If chosen, Elizabeth plans to pursue a master’s program focused on genomic medicine, followed by a master’s degree in global health and epidemiology.

Read more in the Clemson News article.

Associate professor of genetics and biochemistry at Clemson University, Dr. Lukasz Kozubowski earned his bachelor’s and then master’s degrees in pharmaceutical sciences at the Medical University of Warsaw in Poland, whihc is one of the oldest and the largest medical schools in Poland. The first academic department of medicine was established as far back as two centuries ago in 1809.

He then completed his doctorate under the mentorship of Dr. Kelly Tatchell at Louisiana State University Medical Center, studying mechanisms of cell division and morphogenesis (more specifically the biology of septin proteins and related cell signaling involving the PP1 phosphatase). He continued similar investigations under the guidance of Dr. Danny Lew, when he moved to Duke University for his postdoctoral studies.

Subsequently, he performed studies in several labs at Duke (including Joseph Heitman, Andy Alspaugh, and John Perfect) investigating the biology and pathogenicity of a human fungal pathogen Cryptococcus neoformans.

In 2013 he established research program at Clemson University with the main aim to elucidate mechanisms of cell division and stress response in C. neoformans. Dr. Kowzubowski studies C. neoformans to understand the mechanistic cellular processes used by pathogenic microorganisms to allow survival in the infected host. C. neoformans is a major opportunistic fungal pathogen worldwide and a leading cause of morbidity and mortality in AIDS patients.

Dr. Kozubowski’s work with C. neoformans leads to the hypothesis that this pathogen has evolved unique pathways to control cell division in a manner that allows it to survive within a human host. Testing this hypothesis would provide insights into how eukaryotic pathogens adapt to the host environment and could potentially reveal new targets for therapeutic interventions.

In addition to research, Dr. Kozubowski teaches, writes grants and publishes papers in peer-reviewed journals. Read more here.

When senior genetics major Sofia Willey was in middle school, she began having abnormally intense joint pain, something doctors attributed to the rigor of competitive gymnastics and her 20 hour-a-week training schedule.

At first, doctors diagnosed her with hip dysplasia, but that didn’t account for the hypermobility symptoms, scarring and low bone growth. Her doctor then suggested Sofia may have Ehlers-Danlos Syndrome (EDS), specifically the hypermobile subtype. EDS is a rare genetic disorder that affects the connective tissue and can cause weak joints, affecting 1 in 5,000 people.

“I didn’t understand what was happening to me, and no one around me did either.”

Doctors’ limited knowledge of the disorder is due in part to the EDS being under-researched. This has inspired Sofia to pursue a degree in genetics and focus on research while in college.

“It becomes a lot of explaining your own problems to your doctor so they can prescribe or help you find what you need.”

This summer Sofia worked with the Norris Lab at the Medical University of South Carolina on a project related to the complement system and its biological importance in hEDS. Dr. Russell Norris a professor in the Department of Regenerative Medicine and Cell Biology. Norris lab is one of the preeminent labs researching EDS.

Sofia’s specific research aims at finding a diagnostic tool that could use specific protein levels in the blood to determine if a patient has EDS. She focused on changes in the immune system of patients with EDS compared to those without the disease, finding a few significant proteins that had different levels in subjects with EDS than in those without.

Sofia says her time in the Norris lab, which also included patient education, has helped her better understand her disease and problems in her own body. She hopes to change patients’ lives through knowledge of under-recognized diseases.

Read more in the Clemson News article.

If you are looking for senior genetics major Kate Miller, you may find her in the classroom, sports concession stands, Dr. Powder’s lab or on Wednesdays, you’ll see her taking advantage of the $5 sushi deal at Publix.

Both Kate’s focus on community and STEM brought her to Clemson University.

“I came to Clemson because my first visit in middle school caused me to absolutely fall in love with Clemson’s tight-knit community and its emphasis on STEM programs.”

Kate chose her genetics major and her biological sciences minor because she wanted the ability to study both biology and chemistry on a deeper level. Kate says she hopes both her major and minor help in her pursuit of going to Pathologist Assistant school.

“The best part of being in the G&B department has been the personalized support from my mentors and advisors. As a smaller department, I have a strong network with the faculty who make me feel comfortable and supported with my academic and career questions.”

Outside of classes, Kate is involved in extracurriculars but the most important to her is working as a student researcher in Dr. Kara Powder’s lab with the Clemson Creative Inquiry + Undergraduate Research program. In Dr. Powder’s lab she studies craniofacial development of cichlid fishes.

Kate loves working with the fish and notes that this opportunity has greatly enhanced her laboratory skills. Kate’s personal project from this summer explores the developmental effects of estrogen on facial structure.

“Endocrine disruptors such as estrogen have been found in the environment due to pollution, and this research will show what may happen to the facial development of humans if exposed, especially in utero.”

In addition to undergraduate research, Kate is a member and leader of BeakerBox, a CI project where we develop interactive lesson plans for middle school science classrooms in South Carolina. BeakerBox aims to engage 6th-8th graders in the life sciences by keeping science fun and interesting.

“After graduation I plan on going back to school to become a pathologist assistant. My favorite classes right now are Toxicology and Anatomy, which are both fascinating and helping to lay a solid foundation for my future career!”

Director of the Eukaryotic Pathogens Innovations Center (EPIC) and professor of Genetics and Biochemistry Dr. Kerry Smith has taken a role with the Clemson University School of Health Research (CUSHR) as campus research director for the Prisma Health Education and Research Institute (PHERI).

“In this role, I am able to extend my efforts beyond my own laboratory’s research and assist in advancing impactful health-related research in diverse scientific and clinical fields,” said Smith.

PHERI, a collaboration between Prisma Health, Clemson, Furman University and University of South Carolina, seeks to bridge the gap between academics, research, clinical practice and healthcare transformation in a way that is innovative, inter-institutional, inter-professional and interdisciplinary. In his new role, Dr. Smith will work to build and enhance research collaboration between Clemson researchers and clinical faculty from Prisma.

“The increased collaboration will be advantageous for both Clemson researchers and the clinical faculty, as it will enable the Clemson researchers to conduct health-related research in an applied environment that will have a positive impact on individuals,” Smith said. “This will enable the clinical faculty member to offer scientific assistance for innovative interventions that could potentially be implemented outside of Prisma Health–Upstate.”

As campus research director for PHERI, Smith expects these collaborations to continue to generate presentations at conferences for academic researchers and for physicians and healthcare professionals, publications in peer-reviewed journals and external funding.

“Kerry has shown his commitment to our vision of expanding health research at Clemson,” Sherrill said. “We look forward to his success in his new role as Clemson University Campus Research Director for Prisma to enhance our research partnerships and Clemson’s health research mission.”

Read more in the Clemson News article.