Genetics and Biochemistry News

Alumni Stories: Adam Bachman, distiller, musician, reality TV cast member

If you google Adam Bachman II, you will find the normal items – a social media page, some photos of him playing music, some others with the same name – but if you scroll down a bit more you will even find an IMDb page. 2015 biochemistry alum Adam Bachman is a man of many trades, music, distilling, business and more.

When Adam Bachman was an undergrad at Clemson, he built stills from scratch and began producing his own spirits in the woods – the start of his distilling passion. After graduation, Adam went on to be the head distiller at Six & Twenty, a distillery located in the upstate.

“We made all sorts of things from gin to bourbon to vodka. It was a good learning experience for me not just in production but in business practice as well.”

Now Adam is the production manager/head distiller at the Chemist located in Asheville, NC. Adam started at the Chemist when they were only making limited whiskey that he notes as subpar. This led him to start a whiskey program that would be consistent and high quality.

“I developed the single malt whiskey. It has 3 different malts that bounce off one another’s flavor profiles to give a more complex whiskey. It’s distilled in copper pot stills, which is pretty traditional. I also developed a unique rye whiskey for them that should be released sometime next year.”

Photo courtsey of chemistspirits.com

Adam’s day-to-day at the Chemist can look different, between brewing, distilling and working in the rickhouse, which are warehouses used for storing barrels of aging whiskey. However, everyday Adam is putting the knowledge gleaned from his time in the Department of Genetics and Biochemistry to use.

“Mashing, fermentation and distillation of alcohol are all biochemical and chemical processes all relate back to biochemistry. You could take it all the way to the genetics of how grain is being engineered and produced for this industry.”

Photo courtsey of chemistspirits.com

In 2020 Adam was contacted by producers of the tv show Moonshiners: Master Distiller, a reality show where three competitors faceoff each week in a series of challenges focused on making a specific type of spirit. For the episode Adam competed in titled, High Proof Cherry Bounce, the distillers were tasked with making a 300-year-old spirit called Cherry Bounce, a favorite drink of George Washington, nearly lost to time.

“It was a very interesting experience to see show tv works. There were a lot of smoke and mirrors type deal but it was still a very cool experience to do.”

If you can’t find Adam at the distillery, you’ll probably find him practicing or on the stage playing music. He plays resophonic guitar and pedal steel with an artist named James Tucker, as well as with several bluegrass bands in the Asheville area.

Adam’s future plans are to continue to purse his two passions in life: distilling and music, eventually opening his own distillery one day.

“It would be an adventure to be a business owner as well as the main operator.”

Our Students Are Sociable – Justyn Stevens

When senior biochemistry major Justyn Stevens was in high school, he started taking chemistry, biology and anatomy and immediately fell in love with life sciences. That passion coupled with his love of the campus and the knowledge that he wanted to go into the medical field made the biochemistry major at Clemson the perfect place for him.

“Clemson is also always investing in the sciences and helping students and professors with anything they need to help advance their research.”

For Justyn, the Genetics and Biochemistry Department has brought a sense of community with life-long friends and supportive professors. Justyn says his professors and advisors are always there to answer questions just talk about the future and how to prepare.

“If I had one piece of advice for any incoming or current G&B students, it would be to not be afraid to talk to people. Whether that’s professors or other students, you never know who you could meet. I have found some of my best friends in this major as well as some of my favorite professors.”

One of the professors that Justyn has found supportive is Dr. Lukasz Kozubowski. Justyn is currently working in Dr. Kozubowksi’s lab where he is studying Cryptococcus Neoforms. He works closely with Hannah Akahoho, a Ph.D. student in the lab, to better understand the CDC42 gene found in Cryptococcus.

“We are testing how different drugs interact with the organisms and seeing how they affect the budding/replication of Cryptococcus cells. This, in the grand scheme of things, will help our understanding of the CDC42 gene and how to prevent Cryptococcus from replicating and spreading.”

Justyn’s end goal is to go to medical school and become a cardiothoracic surgeon. After graduation, he plans to take a gap year, working as an EMT back in his hometown of Myrtle Beach, SC.

In his free time, Justyn enjoys anything sports related – golfing, throwing football/baseball or playing pickleball. He is studying for the MCAT to go to medical school after his gap year.

Our Students Are Driven – Adam Gatch ’24

Senior biochemistry major Adam Gatch is many things: a student, a hiker, a researcher, a tutor, a Goldwater Scholar, an EMT, a volunteer, a writer, a backpacker – too many things to name.

Originally from Charleston, SC, Adam enjoys Clemson for its people and its proximity to great hiking spots and the mountains.

“It’s been nice to meet others with strong work ethic and passion for learning, and it has been motivating to be surrounded by other students with all kinds of exciting future plans.”

Being involved in many extracurricular activities, Adam’s main focus is his research work with Dr. Feng Ding, who runs the Clemson Multiscale Biophysics Lab in the Department of Physics and Astronomy. With Dr. Ding, he has worked on numerous independent projects investigating the structure and dynamics of various proteins implicated in neurodegenerative disease.

“The major theme of my personal research work is understanding the molecular basis of co-pathologies involving multiple disease-associated proteins. Essentially, many neurodegenerative diseases such as Alzheimer’s and Parkinson’s are characterized by the abnormal accumulation of certain proteins, and the inclusions they form are considered disease hallmarks.”

In some cases, multiple “hallmark” proteins are found in the same pathological assembly or in closely associated assemblies of each protein. Adam’s work seeks to elucidate the molecular mechanisms that enable the proteins to interact and give rise to these co-pathologies, and additionally to understand how that interaction can affect clinical presentation and disease outcome.

From this project, Adam has published four articles in peer reviewed journals with his group, including one first-author paper recently published titled, TDP-43 Promotes Amyloid-Beta Toxicity by Delaying Fibril Maturation via Direct Molecular Interaction in ACS Chemical Neuroscience. In addition, he was awarded a $10,000 NIH REU grant to support his summer research with Dr. Ding.

Adam’s research experience doesn’t stop there; he is involved in the Clemson University Clinical Undergraduate Research Experiences in Surgery (CURES) and has shadowed neurologists at MUSC. Also, he is involved in the Drug Design, Development, and Delivery (4D) lab led by Dr. Jeoung Soo Lee in the Department of Bioengineering, which is focused on nanoparticle-based therapeutics for traumatic brain injury and spinal cord injury.

“In contrast to my computational biophysics research, the 4D lab utilizes in vivo and in vitro experiments, using rats to study the effectiveness of the treatments developed by the group. While Dr. Ding’s lab appealed to me because of my strong interest in neurodegeneration and molecular-level study of disease, Dr. Lee’s lab was perfect for exploring another clinical interest of mine, namely traumatic brain injury.”

In addition to research work, Adam is an EMT on the weekends, a tutor for CH 1010 and 1020 at the Academic Success Center, a member of the College of Science Student Advisory Board, a volunteer at the Paw Pantry and a member of the Clemson Debate Team.

“In my [EMT] work, I have cared for many patients with highly advanced forms of neurodegenerative disease, which reinforces my motivation to study these diseases in the lab. These experiences have been hugely impactful in affirming my commitment to my future career as a physician-scientist.”

After graduation Adam plans to take a couple gap years traveling around Europe before applying to a number of MD-Ph.D. programs in neuroscience. Afterward, he plans to complete medical residency in neurosurgery and lead a research-intensive career as an academic neurosurgeon at a medical university.

“I plan to continue working on highly interdisciplinary research throughout my Ph.D. training and later in my career, hope to one day lead a successful lab.”

Ph.D. student’s internship broadens career path

Jessica Aycock is a second year Ph.D. student in Dr. Stephen Dolan’s lab housed in the Eukaryotic Pathogens Innovation Center (EPIC) at Clemson University. This fall she had the opportunity to intern at IDeA National Resource for Quantitative Proteomics at the Winthrop P. Rockefeller Cancer Institute at University of Arkansas for Medical Sciences (UAMS) in Little Rock, AK.

The IDeA National Resource for Quantitative Proteomics Internship program is designed to provide a unique opportunity for the next generation of scientists to explore an alternative career option in biomedical research by gaining experience in a national resource and core facility environment. Interns are encouraged to bring proteomics samples related to their project, enabling them to work on their own research while they are interning.

Jessica spent two weeks at IDeA National Resource for Quantitative Proteomics gaining a unique hands-on research experience which included managing the entire behind the scenes proteomics workflow – sample prep, mass spectrometry and downstream bioinformatics processing – on her own Ph.D. research samples.

“Not only did I deepen my understanding of my own research, but the experience also broadened my perspective of career opportunities beyond traditional paths.”

In addition, Jessica learned the ins and outs of mass spectrometers including instrumentation, operation and contribution to data acquisition. She also had the chance to explore career options outside of industry and academia, learning how a national core facility functions.

“Learning the intricacies of proteomics through participating in the IDeA National Resource for Quantitative Proteomics internship was an amazing, eye-opening experience. Moving forward, I plan to use these insights to advance my research in the Dolan Lab and explore new directions in the field of proteomics!”

IDeA National Resource for Quantitative Proteomics provides unmatched and cost-effective access to state-of-the-art quantitative proteomics platforms and education, outreach and training opportunities that will increase the capacity of National Institutes of Health-funded investigators to perform cutting-edge biomedical research.

Student Allen Gomez researches yellow camellias

Yellow camellias are far rarer than white, pink and red, found only in south China and Vietnam. Senior biochemistry major Allen Gomez’s research aims to make propagation and growing of yellow camellias easier.

Gomez’s research is done through the Creative Inquiry + Undergraduate Research program with associate professor Dr. Haiying Laing, whose research focuses on the application of genetics and genomics to improve economically important traits in plants.

“I think it’s really interesting how gene editing and being able to modify and improve certain aspects of different organisms through genetics works,” said Gomez.

Working with first-year Ph.D. student Roger Zhang he has investigated the expression levels of auxin response factor (ARF) genes in Camellia nitidissima, aiming to determine how ARF genes were regulated in yellow camellias, possibly leading to the ability to determine a method to induce adventitious roots and develop a treatment method that would improve the rooting ability of yellow camellias.

Gomez’s end goal is to attend medical school and become a surgeon. He says the research he has done through this project gives him valuable research experience to bolster his medical school applications and allows him to hone skills he’ll use throughout his career in medicine.

“It shows that I am able to follow instructions step-by-step, take precise notes, solve problems, work with others, interpret data and know the importance of sterility. I’ll use those skills in medical school and as a surgeon,” he said.

Gomez’s desire to become a surgeon stems from a childhood experience.
When Gomez was 10, he lived in Ecuador. After falling off monkey bars at the playground and breaking his wrist, it was four days before he could get the surgery he needed. That sparked his interest in surgery and a desire to help bring more medical services to rural areas in Ecuador.

“My experiences at Clemson helped solidify my belief that pursuing a medical career is the right thing to do.”

Our Students Are Collaborative – Meet Morgan Kuess ’25

You may have seen Morgan in your favorite yoga class, walking around the Life Sciences Building on her way to lab, reading a new book in the library or she may have served you a coffee at All In Coffee Shop.

As an Honors senior biochemistry major from Fort Mill, SC, Morgan likes being around like-minded people in the Genetics and Biochemistry Department.

“The Genetics and Biochemistry Department has introduced me to some of my best friends and has exposed me to so many of our incredible research faculty. My research mentors and professors have continuously inspired me to become a better student and researcher, and I would not be where I am today without each one of them.”

For three years, Morgan performed research in Professor Dr. Hong Luo’s lab, which is focused on transgenic turfgrass modifications in hopes of developing genetic lines that are less susceptible to environmental stressors like heat and drought.

“My primary role was in transgene containment to prevent genetic contamination with naturally occurring grass species, but the work that was published dealt with a miRNA that improved crop yield.”

Morgan has had many successes in Dr. Luo’s lab, even having a publication accepted with one of his graduate students. The article is titled “MicroRNA169 integrates multiple factors to modulate plant growth and abiotic stress responses.”

The summer of her freshman year she spent at the Center for Human Genetics under Drs. Trudy Mackay and Robert Anholt studying the genetic underpinnings of cocaine use disorder in Drosophila melanogaster. Morgan researched the effects of a multiple-day period exposure to cocaine in fly lines that were genetically predisposed to cocaine addiction.

“Coupled with behavioral assays that proved cocaine exposure led to adverse physical effects, my research reinforced the idea that prolonged cocaine use disorder has a genetic component.”

This summer, Morgan was granted a position in the Duke PRIME-Cancer program in Dr. Stefanie Sarantopoulos’ lab studying chronic Graft-versus-Host Disease, which is an autoimmune disease that can develop in leukemia and lymphoma patients that receive stem cell transplants. Here, Morgan’s focus was studying the role of the TLR7-IRF5 signaling pathway on the activation of lung fibroblasts, which leads to fibrotic airway diseases that are common in cGVHD patients.

“My experience here was great! I became close with my mentors and the members of the lab, and the program exposed us to so many great researchers around Duke. It was great to meet students from around the country with similar interests!”

When Morgan was named a Seifert Scholar the summer after her sophomore year, she began working in Dr. Kerry Smith’s lab, which is her main focus this year. Her research in Dr. Smith’s lab is centered on the importance of glycolysis in Cryptococcus neoformans, which is a primary cause of fungal meningitis. She has been working to identify biochemical inhibitors that target different steps of glycolysis to prevent their growth as potential therapeutic interventions for patients with fungal meningitis.

“I have identified Baicalein as a potential enolase inhibitor, so I am diving further into that and plan to develop an enolase knockout strain to confirm the phenotypic effects of both. I plan to apply for departmental honors with this project this fall.”

Morgan’s future plans include applying to graduate school this fall to obtain her Ph.D. in biochemistry or pharmacology, hoping to work in project leadership in the pharmaceutical industry. After her Ph.D., she plans to get her Master’s of Public Health to become involved in researching disparities in drug and medical care access in underserved and underrepresented communities around the world.

“My international travels have inspired me to gain work and research experience out of the country as well, so I will be looking for degree and training opportunities abroad.”

Alumni Stories: Dr. Matthew Angel, Army Biochemist

As a child, Dr. Mathew Angel was on the Clemson campus quite often for academic events, basketball camps in the summers, going to sporting events or visiting faculty members with his dad, who was a high school physics teacher. So, by the time he started his freshman year, he knew his way around.

“I started at Clemson in 2003 as a General Engineering major but left school after my third semester to enlist in the Army for about 2.5 years, deploying to Iraq for a year during that time.”

Angel returned to Clemson in Fall 2007 as a biochemistry major on an Army ROTC scholarship, where he was the involved in and the president of both the Biochemistry and Genetics Club and the Clemson University Student Veterans Association. Upon graduating in 2010 with a degree in Biochemistry and Genetics and a minor in Military Leadership, Angel commissioned into the Army as a Medical Service Corps officer and spent six years as a Field Medical Officer in the Third Infantry Division at Fort Stewart, Georgia.

“I was selected by the Army to go back to school to pursue my graduate degree, so I returned to Clemson on a fully-funded Army educational program (I just can’t stay away from that place for long!) in 2017, still on active duty, and graduated in 2022 from Dr. Cheryl Ingram-Smith’s lab with my Ph.D. in Biochemistry and Molecular Biology. Dr. Ingram-Smith was and still is an amazing mentor for me, and we continue to communicate regularly.”

Angel currently works as an Army Biochemist at the Defense Centers for Public Health – Aberdeen in Maryland, which has the largest public health laboratory in the Department of Defense (DoD). He works in the Molecular Biology Division as the Chief of the Microorganism Analysis Branch. Angel’s lab designs and implements molecular biology laboratory methods to conduct biosurveillance of environmental matrices in order to protect the health of our populations.

“We primarily conduct testing of drinking water and wastewater to detect, identify, and quantify biological threats of interest, specifically human pathogens of concern and antimicrobial resistance markers of clinical significance. We also work to establish wastewater surveillance programs, which I first learned about while I was in grad school at Clemson during the COVID-19 pandemic.”

Angel has been involved as the DoD co-lead on wastewater surveillance in developing policy and doctrine at the DoD level as well as forming partnerships and collaborations with DoD and U.S. Government partners. In the wastewater surveillance project, he is using specific technologies, namely quantitative polymerase chain reaction (qPCR) and next-generation sequencing (NGS) to detect, identify, and quantify the presence of pathogens of concern in our populations.

“This was absolutely not the path I envisioned taking in my career. When I decided to switch majors from engineering to biochemistry, I did so because I enjoyed biology and chemistry in high school and thought it might be more interesting for me to get into the life sciences. At Clemson, I learned indirectly about public health and pathogen surveillance during the pandemic. All that led me to what I’m doing now!”

Angel plans to retire from the Army in about six years, during which time he intends to stay involved in his current public health work. Eventually he would like to move back to South Carolina and is interested in returning to Clemson as a faculty member. Dr. Matthew Angel is originally from Easley, SC, currently lives in Maryland, but loves coming back to Clemson to visit!

Stundets present research at the 8th Annual Summer CI+UR Showcase

Genetics and biochemistry students who participated in the Summer CI + UR program presented posters of their research at the Summer Showcase on August 20th in the Watt Family Innovation Center. Students included Kristen Gulbrandsen, Elizabeth Caldwell, Helen Kiser, Brooke Dillingham, Kate Miller, Kaite Cross and Britana Myers.

Kristen Gulbrandsen ’25, biochemistry

Title: “Exploring Environmental Factors that Influence the Inhibition of Clostridium innocuum on Enterococcus faecalis”

Elizabeth Caldwell ’24, genetics

Title: “Characterization of different UBTF tandem duplications in acute myeloid leukemia”

Helen Kiser ’24, genetics

Title: “Characterization of mitochondrial genomes and phylomitogenomic analyses confirms the existence of cryptic species in Gonodactylaceus”

Brooke Dillingham ’24, genetics

Title: “Identification of DNA Binding Mutants in BRCA2”

Kate Miller ’24, genetics

Title: “Examining facial development in response to β-estradiol exposure using Tropheops Sp. ‘Red Fin’ cichlids”

Katie Cross ’25, biochemistry

Title: “The effects of progesterone exposure on the craniofacial development of Pseudotropheus livingstonii fish embryos”

Britana Myers ’24, genetics

Title: “Truncating MEILB2 and DNA repair”

Dolan reveals groundbreaking information about the lungs of people with cystic fribrosis

Dr. Stephen Dolan has revealed previously unknown information about how bacteria and fungi interact in the lungs of people with cystic fibrosis (CF), which could lay the groundwork for more effective treatment and detection of polymicrobial lung infections in people with CF.

CF, one of the most common genetic diseases in the United States, causes an abnormally sticky, thick mucus to build up in the lungs, providing the perfect breeding ground for infections.

“Everybody at home knows somebody affected by CF because it’s so prevalent,” said Dolan, who said his CF-related research allows him to do high-level microbiology that is also clinically relevant.

Dolan working with his collaborators at Georgia Tech have uncovered how two of the most commonly found microbes in the lungs of people with CF, Pseudomonas aeruginosa and Aspergillus fumigatus, interact molecularly in the lungs they infect.

“Cystic fibrosis results in a wide range of challenging symptoms which impact the entire body, but repeated lung infections leading to lung damage is the major cause of mortality. It’s mostly bacteria and fungi like Pseudomonas and Aspergillus which are responsible for these infections.” said Dolan.

Dolan, who conducts his research at the Clemson University Eukaryotic Pathogens Innovation Center (EPIC),  also uncovered a previously unknown toxin detection system that allows the two microbes Pseudomonas aeruginosa and Aspergillus fumigatus to co-exist in the sputum in CF lungs.

“It appears that ecologically, over millions of years, these microbes have been growing together in soil and have developed elaborate strategies to compete for space and nutrients, and then when they get into humans, those in-built mechanisms have allowed them to coexist and cause serious infections,” he said.

Dolan is able to conduct his research through the support of the Cystic Fibrosis Foundation and a Career Transition Award (K22) from the National Institute of Allergy and Infectious Diseases.